Antoni was born in Freeport, Bahamas. She received her BA from Sarah Lawrence College in New York, and earned her MFA from the Rhode Island School of Design in 1989. She has exhibited at the Whitney Museum of American Art, Museum of Modern Art, S.I.T.E. Santa Fe, the Irish Museum of Modern Art, Dublin, and the 1993 Venice Biennale, among many others. Antoni is the recipient of several prestigious awards including a John D. and Catherine T. MacArthur Fellowship in 1998, the Larry Aldrich Foundation Award in 1999, The John Simon Guggenheim Memorial Foundation Fellowship in 2011 and a 2012 Creative Capital Artist Grant. She currently resides in New York City.